A novel protein

Our Laboratory Follows the Science
Let Science Tell the Story

Our recent studies have revealed novel signaling functions of RGS proteins in the nucleus, in neuronal differentiation and development, and in DNA damage signaling responses. We identified an RGS polymorphism (gene variant) in humans associated with a significant reduction in the risk of cancer, providing the first link between RGS protein expression and cancer. These studies raise questions of considerable interest and importance concerning the role of RGS proteins in cellular regulation by mechanisms both dependent on and independent of their regulatory actions on G proteins. Some current projects include identifying novel RGS protein interaction partners, anti-sense and transgene technologies to probe physiological roles of RGS proteins, defining the role of nuclear RGS proteins and determining the mechanisms regulating RGS gene expression.

Our philosophy is to let the science seek the truth.

Rory A. Fisher, PhD

Laboratory Director

Zili Luo, MD, PhD

Postdoctoral Scholar

Katelin Ahlers, PhD

Postdoctoral Scholar

Bandana Chakrvarti, PhD

Postdoctoral Scholar

Jianqi Yang, PhD

Associate Research Scientist, Fisher Laboratory

Recent Publications

RGS6 Protein's Role in Cancer and Alcohol Treatment

Protein controls both alcohol craving and organ damage

Study suggests targeting RGS6 protein might allow both treatment of alcoholism and prevention of alcohol-induced heart and liver damage